PHI2WEB can be used in two different modes: User and Member. The User mode allows a user to browse the database, but they cannot update it. The Member mode, in turn, allows the user to update the existing HPI data, vote whether or not the extracted HPI data are correct, and insert a new HPI entry.

User starts by entering at least one search term into the corresponding search box (shown in grey are examples of search terms):

The search will result in a series of matches:

The results are capped by 500 interactions due to the load time. To reduce the number of results, User is advised to provide additional search terms. Each row represents a single interaction between one host protein and one pathogen protein. Multiple interactions per one abstract are possible. The interaction entry is accompanied by the Status icon, Correctness votes and the Abstract button. The Status icon reflects currently reported status of an interaction entry: correct interaction (green), incorrect interaction (red) and interaction entry with updated information made by a Member, but not yet approved by a curator (orange). The Correctness votes show the number of votes by the members who thought that the interaction entry is correct (green) or fully/partially wrong (red). Clicking the abstract button opens up the Abstract page for the corresponding interaction entry. For example, clicking the Abstract button for entry 434 produces:

The Abstract page includes the basic abstract information as well as the history of the previous modifications made by the Members to this interaction. It also provides the ability to highlight the corresponding host organism, host protein/gene, pathogen organism and the pathogen protein/gene terms in the abstract by checking some or all of the corresponding checkboxes on top of the page:

Automated extraction on host-pathogen interactions from biomedical literature is a very challenging problem. Even state-of-the-art methods are prone to errors when extracting the HPI data. Thus, the main focus of PHI2WEB portal is to promote contribution from the scientific community on curation of the data. The portal provides flexible tools to do so.

To get the capability of modifying the data in the database, a user needs to register first by providing their name, email and affiliation in the Register form retrieved by clicking the ‘Register’ link:

Once registered User becomes Member and can log in using their username and password. After logging in, Member will have all capabilities they had when they were in User mode. In addition, they can start proposing modifications to the HPI data as well as vote on the correct/incorrect entries, similar to using the ‘Like ‘ button on Facebook or ‘Like/Dislike’ on YouTube. These capabilities are immediately available after the Member searches for the interaction and retrieves the results:

To vote, whether the information provided in the HPI entry is correct, press ‘Yes’, if such interaction doesn’t exist or requires modification press ‘No’. Once the ‘No’ button has been pressed, members will be prompted to enter some details. Here is an example of pressing ‘No’ for entry 336 above:

They can decide to modify the entry details that they think should be corrected; they can also disregard the request by pressing Cancel. Here we will submit the changes to the interaction by first selecting the ‘Interaction exists but has to be changed’ radio button, then modifying the entries for the pathogen and host proteins and clicking ‘Submit’ button. The updated result is shown below:

Last, the user can enter the information about new HPI interaction and/or Abstract by clicking ‘New; button in the top menu and submitting the requested information about the HPI:

All new or modified interactions are then sent to one of the database curators, experts in host-pathogen interactions, for approval.